Fresh analysis reveals that patients who stop using blockbuster slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who stop traditional diet and exercise regimens.
Research printed in a prominent health publication shows that while obese individuals can lose about a fifth of their total mass while using the jabs, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"People using such medications must be aware of the potential of rapid rebound weight gain when the treatment is stopped," warns expert Dr. Susan Jebb.
This pace of recovery means a reversion to original weight in about 18 months.
Weighing Treatments
The analysis, which looked at 37 of studies involving thousands of participants, compared the outcomes of these new drugs with older methods.
Researchers note that individuals who shed pounds through diet and exercise generally experience a less rapid weight regain—approximately 0.1 kg a month—post-intervention.
Explaining the Fast Rebound
Nutrition scientists believe the mechanism of the jabs explains the amplified rebound.
The injections imitate a natural hormone called GLP-1, which moderates appetite.
"Sustained high doses of GLP-1 levels several times higher than normal may cause the system to generate a reduced amount of its endogenous hormone, and may also lessen sensitivity to its effects," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this hormone supplement leads to appetite is no longer kept in check, making overeating far more likely."
A Chronic Disease?
The NHS advise the jabs for individuals with obesity-related health risks, alongside recommended lifestyle changes.
Many experts contend that, given the likelihood of relapse, the treatment should be considered long-term.
This perspective is supported by pharmaceutical companies, who say that the results "underscore the long-term character of excess weight," comparing it to managing diseases like diabetes.
Patient Accounts
Users who have stopped the medication explain a intense resurgence of cravings.
"It felt as if a trigger that goes on and you're instantly ravenous," said one woman.
The struggle is exacerbated if patients have not adopted permanent lifestyle or habit changes during treatment.
Significant Adoption
Recent estimates show that a significant number of people in the UK have used these injections in the past year, with desire being substantial.
- Adoption is higher among females than men.
- The 40s and 50s demographic shows the highest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, clinicians caution that while these medications are powerful agents for weight loss, they are not a standalone cure and lasting health benefits hinges on ongoing lifestyle changes.
